One of the major challenges in the post-genomic era is to confirm and understand the function of expressed proteins in eukaryotic cells. The Scanning Ion-selective Electrode Technique (SIET) is a unique tool to meet this challenge. The SIET non-invasively measures both ionic concentrations and ionic fluxes in aqueous media with a spatial resolution of less than 10 micrometers with picomolar sensitivity. The SIET measures the extracellular fluxes in and out of living biological membranes in-vitro. Ca²⁺, H⁺, Cl^-, K⁺, Cd²⁺, Al³⁺, Mg²⁺, O₂ and NO are some of the ions/molecules that can be measured at present, and more ion and molecular species will be available in the near future. Some of the many applications of this technique for example, ionic flux measurements in both animal and plant cells demonstrate the unique advantages of the SIET compared to other techniques. The SIET can measure extra-cellular ion movement in such a way that it provides information that has been only theoretical.

     YoungerUSA Company, one of the world leading companies in this area, is a coalition company with Applicable Electronics, Inc., who is specialized in design, develope and manufacturing the Non-invasive Ion Probe System and Scanning MicroElectrode System. YoungerUSA is focusing on marketing, system installation, maintenance and training around the world.